Prof. Pavel Krsek, MD, PhD
Physician
Clinical Electrophysiology, Neuroimaging, Molecular Genetics Groups
Department of Paediatric Neurology, Second Faculty of Medicine, Charles University and Motol University Hospital
Scientific background
Paediatric neurologist, epileptologist, current Head of the Department of Paediatric Neurology at Second Faculty of Medicine, Charles University and Motol University Hospital, Chairman of the Czech League Against Epilepsy, past Chairman of the Czech Society of Paediatric Neurology of the Czech Medical Association of J. E. Purkyně, and member of the EPNS Board. Pavel Krsek primarily focuses on the issue of drug-resistant epilepsy in children and the possibilities of its surgical management; specifically addressing issues related to malformations of cortical development, tuberous sclerosis, genetic causes of epilepsy and their significance for patient prognosis, as well as intraoperative monitoring and factors affecting the quality of life in children with epilepsy.
Research interests
See above.
Selected publications
Straka B, Splitkova B, Vlckova M, Tesner P, Rezacova H, Krskova L, Koblizek M, Kyncl M, Maulisova A, Bukacova K, Uhrova-Meszarosova A, Musilova A, Kudr M, Ebel M, Belohlavkova A, Jahodova A, Liby P, Tichy M, Jezdik P, Zamecnik J, Aronica E, Krsek P.
Genetic testing in children enrolled in epilepsy surgery program. A real-life study. Eur J Paediatr Neurol. 2023 Nov;47:80-87. https://doi.org/10.1016/j.ejpn.2023.09.009.
Janca R, Jezdik P, Ebel M, Kalina A, Kudr M, Jahodova A, Krysl D, Mackova K, Straka B, Marusic P, Krsek P.
Distinct patterns of interictal intracranial EEG in focal cortical dysplasia type I and II. Clin Neurophysiol. 2023 Jul:151:10-17. https://doi.org/10.1016/j.clinph.2023.03.360.
Straka B, Hermanovska B, Krskova L, Zamecnik J, Vlckova M, Balascakova M, Tesner P, Jezdik P, Tichy M, Kyncl M, Musilova A, Lassuthova P, Marusic P, Krsek P.
Genetic Testing for Malformations of Cortical Development: A Clinical Diagnostic Study. Neurol Genet. 2022 Sep 27;8(5):e200032. https://doi.org/10.1212/NXG.0000000000200032.
Sanders MW, Van der Wolf I, Jansen FE, Aronica E, Helmstaedter C et al. , as the European Epilepsy Brain Bank Consortium (EEBB).
Outcome of Epilepsy Surgery in MRI-Negative Patients Without Histopathologic Abnormalities in the Resected Tissue. Neurology. 2024 Feb 27;102(4):e208007. https://doi.org/10.1212/WNL.0000000000208007.
Huschner F, Głowacka-Walas J, Mills JD, Klonowska K, Lasseter K, Asara JM, Moavero R, Hertzberg C, Weschke B, Riney K, Feucht M, Scholl T, Krsek P, Nabbout R, Jansen AC, Petrák B, van Scheppingen J, Zamecnik J, Iyer A, Anink JJ, Mühlebner A, Mijnsbergen C, Lagae L, Curatolo P, Borkowska J, Sadowski K, Domańska-Pakieła D, Blazejczyk M, Jansen FE, Janson S, Urbanska M, Tempes A, Janssen B, Sijko K, Wojdan K, Jozwiak S, Kotulska K, Lehmann K, Aronica E, Jaworski J, Kwiatkowski DJ.
Molecular EPISTOP, a comprehensive multi-omic analysis of blood from Tuberous Sclerosis Complex infants age birth to two years. Nat Commun. 2023 Nov 23;14(1):7664. https://doi.org/10.1038/s41467-023-42855-6.