Aakash Pant
Student, researcher
Department of Physiology, Second Faculty of Medicine, Charles University
Scientific background
Since 2020 I have been working on the electrophysiology in rats with a particular interest in cardiac and respiratory events surrounding seizures.I am particularly interested in these events in relation to Sudden Unexpected Death in Epilepsy. In this work I have specialized in in vivo electrophysiology recordings in a tetanus toxin model of epilepsy, surgery in rats and proper handling techniques along with analysis of electrophysiological data.
Research interests
Of particular interest to me is the subcortical control of respiration and the networks involved in controlling the physiological pattern generation during respiration. The coordination of brain stem structures with higher subcortical structures, namely the Hippocampus and Amygdala, is of particular interest. The structures involved in Hypercapnic ventilatory response and their potential failure during ictal events leading to seizure-related deaths could lead to a better understanding of Sudden Unexpected Death in Epilepsy and in turn help direct future treatment and prevention strategies to better inform people living with epilepsy what they should and should not be concerned with.
In addition, I am interested in novel surgical techniques in epilepsy, in particular the use of neuromodulation and minimally invasive techniques.
Selected publications
Liška K, Pant A, Jefferys JGR. Diaphragm relaxation causes seizure-related apnoeas in chronic and acute seizure models in rats. Neurobiol Dis. 2024 Nov 14;203:106735. doi: 10.1016/j.nbd.2024.106735
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