prof. MUDr. Jakub Otáhal, Ph.D.

jakub.otahal@lfmotol.cuni.cz

Ústav patologické fyziologie, 2. LF UK

NeuroImaging

Team leader

Already at medical school, I started working at the Institute of Normal, Pathological and Clinical Physiology of the 3rd Faculty of Medicine of the Charles University in research on ischemic stroke. I regularly interned with Prof. Benes at the neurosurgical department of Masaryk Hospital in Ústí nad Labem. I did my postgraduate studies under the supervision of Prof. František Maršík (Institute of Thermomechanics of the CAS) and Prof. Pavel Mareš (Institute of Physiology of the CAS). After obtaining my PhD, I went to Berlin for a “fateful” postdoc at the Institute fur Neurophysiologie (Charité – Universitats Medizine Berlin) led by Prof. Uwe Heineman and I collaborated with Prof. Oliver Kann (University of Hedelberg), Dr. Richard Kovacs and other excellent scientists. After my return, I worked at the Institute of Physiology of the CAS, where I formed a group focused on nervous tissue metabolism (collaboration with Dr. Jaroslava Folbergrova). Between 2010-5 I was deputy director of the institute. After the establishment of the EpiReC research centre and intensive collaboration with clinicians from Motol University Hospital, I moved to my current workplace, the Institute of Pathological Physiology of the 2nd Faculty of Medicine of Charles University. In addition to teaching and solving scientific projects, I am also involved in the transfer and commercialization of intellectual property and technology as a “Technology Scout of the 2nd Faculty of Medicine”.

Research interests

In my work I try to describe the changes that take place during the development of acquired epilepsy. I focus mainly on changes in energy metabolism and cerebral perfusion. I try to translate the knowledge that my colleagues and I acquire into clinical practice. We focus on improving the diagnosis of epilepsy using imaging methods, especially magnetic resonance imaging. In close collaboration with the Department of radiology, Department of Neurology, Department of Pediatric Neurology, we are validating for clinical practice the assessment of non-Gaussian diffusion (DKI), perfusion (DSC, pcASL) blood-brain barrier permeability (DCE, DEBBIE ASL) and newly electrical properties of tissue (MR-EPT).

The most important publications

1: Danačíková Š, Straka B, Daněk J, Kořínek V, Otáhal J. In vitro human cell
culture models in a bench-to-bedside approach to epilepsy. Epilepsia Open. 2024
Apr 18. doi: 10.1002/epi4.12941. Epub ahead of print. PMID: 38637998.

2: Bučková BR, Kala D, Kořenek J, Matušková V, Kumpošt V, Svobodová L, Otáhal J,
Škoch A, Šulc V, Olšerová A, Vyhnálek M, Janský P, Tomek A, Marusič P, Jiruška
P, Hlinka J. Structural connectivity-based predictors of cognitive impairment in
stroke patients attributable to aging. PLoS One. 2023 Apr 14;18(4):e0280892.
doi: 10.1371/journal.pone.0280892. PMID: 37058495; PMCID: PMC10104329.

3: Janovska P, Zouhar P, Bardova K, Otahal J, Vrbacky M, Mracek T, Adamcova K,
Lenkova L, Funda J, Cajka T, Drahota Z, Stanic S, Rustan AC, Horakova O, Houstek
J, Rossmeisl M, Kopecky J. Impairment of adrenergically-regulated thermogenesis
in brown fat of obesity-resistant mice is compensated by non-shivering
thermogenesis in skeletal muscle. Mol Metab. 2023 Mar;69:101683. doi:
10.1016/j.molmet.2023.101683. Epub 2023 Jan 30. PMID: 36720306; PMCID:
PMC9922683.

4: Folbergrová J, Ješina P, Otáhal J. Protective Effect of Sulforaphane on
Oxidative Stress and Mitochondrial Dysfunction Associated with Status
Epilepticus in Immature Rats. Mol Neurobiol. 2023 Apr;60(4):2024-2035. doi:
10.1007/s12035-022-03201-x. Epub 2023 Jan 4. PMID: 36598650; PMCID: PMC9984354.

5: Daněk J, Danačíková Š, Kala D, Svoboda J, Kapoor S, Pošusta A, Folbergrová J,
Tauchmannová K, Mráček T, Otáhal J. Sulforaphane Ameliorates Metabolic Changes
Associated With Status Epilepticus in Immature Rats. Front Cell Neurosci. 2022
Mar 15;16:855161. doi: 10.3389/fncel.2022.855161. PMID: 35370554; PMCID:
PMC8965559.

Researcher ID

B-5833-2012