Monika Rehorova, MSc, PhD
Post-doctoral fellow
monika.rehorova@lfmotol.cuni.cz
Laboratory of Neural Circuit Optophysiology
Department of Physiology, Second Faculty of Medicine, Charles University
Scientific background
I studied Molecular Biology and Genetics at the Faculty of Science, Masaryk University. I obtained my Ph.D. in Neuroscience at Second Faculty of Medicine, Charles University in 2020. During my study, I focused on the molecular mechanisms involved in the pathogenesis of amyotrophic lateral sclerosis. Apart from mastering various molecular biology and biochemistry techniques, I gained extensive expertise in the cultivation of human pluripotent stem cell under different culture conditions, as well as in reprogramming human induced pluripotent stem cells.
Currently, I am working as a postdoctoral researcher at the Department of Physiology at Second Faculty of Medicine where I have co-adopted in-utero electroporation procedure, mouse brain microsurgery and cranial window preparation together with advanced in vivo single-cell imaging techniques, mostly focusing on in vivo calcium imaging. My present work focuses on the investigation of mechanisms of epileptogenesis and ictogenesis at single-cell level in vivo in a mouse model of focal cortical dysplasia.
Research interests
Focal cortical dysplasia, inhibitory interneurons, brain circuits, seizure spreading
Selected publications
Abdelfattah AS, Zheng J, Singh A, Huang YC, Reep D, Tsegaye G, Tsang A, Arthur BJ, Rehorova M, Olson CVL, Shuai Y, Zhang L, Fu TM, Milkie DE, Moya MV, Weber TD, Lemire AL, Baker CA, Falco N, Zheng Q, Grimm JB, Yip MC, Walpita D, Chase M, Campagnola L, Murphy GJ, Wong AM, Forest CR, Mertz J, Economo MN, Turner GC, Koyama M, Lin BJ, Betzig E, Novak O, Lavis LD, Svoboda K, Korff W, Chen TW, Schreiter ER, Hasseman JP, Kolb I. Sensitivity optimization of a rhodopsin-based fluorescent voltage indicator. Neuron. 2023 May 17;111(10):1547-1563.e9. https://doi.org/10.1016/j.neuron.2023.03.009